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A Randomized Trial of a Schlemm's Canal Microstent with Phacoemulsification for Reducing Intraocular Pressure in Open-Angle Glaucoma
2014
Purpose To assess the safety and effectiveness of the Hydrus Microstent (Ivantis, Inc, Irvine, CA) with concurrent cataract surgery (CS) for reducing intraocular pressure (IOP) in open-angle glaucoma (OAG). Design Prospective, multicenter, randomized, single-masked, controlled clinical trial. Participants One hundred eyes from 100 patients 21 to 80 years of age with OAG and cataract with IOP of 24 mmHg or less with 4 or fewer hypotensive medications and a washed-out diurnal IOP (DIOP) of 21 to 36 mmHg. Methods On the day of surgery, patients were randomized 1:1 to undergo CS with the microstent or CS alone. Postoperative follow-up was at 1 day, 1 week, and 1, 3, 6, 12, 18, and 24 months. Wa…
Genome-wide DNA profiling of marginal zone lymphomas identifies subtype-specific lesions with an impact on the clinical outcome
2011
Abstract Marginal zone B-cell lymphomas (MZLs) have been divided into 3 distinct subtypes (extranodal MZLs of mucosa-associated lymphoid tissue [MALT] type, nodal MZLs, and splenic MZLs). Nevertheless, the relationship between the subtypes is still unclear. We performed a comprehensive analysis of genomic DNA copy number changes in a very large series of MZL cases with the aim of addressing this question. Samples from 218 MZL patients (25 nodal, 57 MALT, 134 splenic, and 2 not better specified MZLs) were analyzed with the Affymetrix Human Mapping 250K SNP arrays, and the data combined with matched gene expression in 33 of 218 cases. MALT lymphoma presented significantly more frequently gain…
Sports, Executive Functions and Academic Performance: A Comparison between Martial Arts, Team Sports, and Sedentary Children
2021
It is well known that curricular physical activity benefits children’s executive functions and academic performance. Therefore, this study aimed to determine whether there is an influence of extracurricular sports on executive functions and academic performance. However, it is less known which specific types of the sport better enhance executive functions in children
AMPA receptor GluA2 subunit defects are a cause of neurodevelopmental disorders.
2019
AMPA receptors (AMPARs) are tetrameric ligand-gated channels made up of combinations of GluA1-4 subunits encoded by GRIA1-4 genes. GluA2 has an especially important role because, following post-transcriptional editing at the Q607 site, it renders heteromultimeric AMPARs Ca2+-impermeable, with a linear relationship between current and trans-membrane voltage. Here, we report heterozygous de novo GRIA2 mutations in 28 unrelated patients with intellectual disability (ID) and neurodevelopmental abnormalities including autism spectrum disorder (ASD), Rett syndrome-like features, and seizures or developmental epileptic encephalopathy (DEE). In functional expression studies, mutations lead to a dec…
Links between adverse childhood experiences, psychopathological symptoms and recidivism risk in juvenile delinquents
2020
Research in the field of developmental psycho-criminology shows that conduct disorders and deviant behaviours are frequently associated with traumatic and adverse developmental experiences. Personality traits and psychopathological symptoms also increase the risk of criminality. However, the role of psychopathological symptoms in the relationship between adverse childhood experiences and offending has rarely been researched. The present study was designed to throw further light on these issues by analysing risk factors in a group of adolescents and young adults in a juvenile detention centre in southern Italy. Results support the idea that the accumulation of risk factors is a major factor…
Improving survival with deferiprone treatment in patients with thalassemia major: A prospective multicenter randomised clinical trial under the auspi…
2009
The prognosis for thalassemia major has dramatically improved in the last two decades. However, many transfusion-dependent patients continue to develop progressive accumulation of iron. This can lead to tissue damage and eventually death, particularly from cardiac disease. Previous studies that investigated iron chelation treatments, including retrospective and prospective non-randomised clinical trials, suggested that mortality, due mainly to cardiac damage, was reduced or completely absent in patients treated with deferiprone (DFP) alone or a combined deferiprone-deferoxamine (DFP-DFO) chelation treatment. However, no survival analysis has been reported for a long-term randomised control …
Pobreza en España: jóvenes y mujeres en los espacios sociales de la vulnerabilidad
2011
This number of Quaderns presents the results of two research projects of the program I+D+i financed by the Spanish Ministry of Education for the period 2008 to 2011. The first project is called 'New poverty and social exclusion among youth in Spain' and was supervised by Ph. D. Ignasi Brunet. The second project was developed under the name of 'Poverty, social exclusion and gender inequality in Spain' and was supervised by Ph. D. Ángel Belzunegui. Both projects counted with a group formed by researchers from six Spanish universities from different regions where field work was carried out: Andalucía, Aragón, Cataluña, Comunidad Valenciana, Murcia y País Vasco. The first project has analyzed p…
Integrating Retirement and Long-Term Care (LTC) Annuities Using a Notional Defined Contribution (NDC) Framework
2014
This paper examines the possibility of embedding public long-term care (LTC) insurance within the retirement pension system, i.e. introducing life care annuities (LCAs) into a notional defined contribution (NDC) framework. To do this we develop a multistate overlapping generations model (MOLG) that includes the so-called survivor dividend and give special attention to the assumptions made about mortality rates for dependent persons and LTC incidence rates, which largely determine the contribution rate assigned to LTC. The proposed model could be of interest to policymakers because it could be implemented without too much difficulty, it would universalize LTC coverage with a "fixed" cost, an…
Analysis of Teaching Personal and Social Responsibility model-based programmes applied in USA and Spain
2013
Caballero-Blanco P, Delgado-Noguera, MA, Escarti-Carbonell, A. Analysis of Teaching Personal and Social Responsibility model-based programmes applied in USA and Spain. J. Hum. Sport Exerc. Vol. 8, No. 2, pp. 427-441, 2013. Over the last three decades, several studies have applied Hellison’s Teaching Personal and Social Responsibility (TPSR) model; most of them have generated strong empirical evidences that support that theoretical framework. TPSR is a programme for positive youth development through physical activity. This article compares the different studies that have implemented the TPSR model in the United States and Spain. This paper reviews those researches by analysing their key fea…
Agreements regarding the property relations of transnational couples and their effects under the application of the twin regulations
2021
It is a true and verifiable fact that the family institution has evolved over recent decades in Europe and throughout the world, but not uniformly or at the same time. This is because it is influenced by social and cultural connotations specific to each State. All of which are respected under EU Regulations 2016/1103 and 2016/1104. This work analyses the Twins Regulations, that gives the couples the possibility of choosing the jurisdiction (art. 7) and applicable legal system underpinning the property consequences of the marriage and registered partnerships (art. 22.1). However, we try to show you these rules absolute freedom of choice is not granted to the parties, because this freedom is …